Short Description
Measures AST activity to assess liver and heart tissue damage.
Development Stage
Research-Grade Protein & Enzyme Assay Development
Description
Used in conjunction with ALT assays, the ModifiSite™ Aspartate Transaminase Assay Kit calculates hepatotoxicity ratios to provide a comprehensive view of tissue damage in systemic toxicity studies. This rapid kinetic determination supports high-volume toxicity screening, allowing for the efficient evaluation of lead compounds. It is an integral component of standard liver and cardiac safety assessment batteries in pharmaceutical research.
Features
Rapid kinetic determination supports high-volume toxicity screening; Integral component of standard liver and cardiac safety assessment batteries.
Process Relevance
Hepatotoxicity Screening (Systemic)
Application Stage
Pre-clinical Safety
Applications
Used alongside ALT for computing the AST/ALT ratio in clinical diagnostics.
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
Absorbance at 340 nm
Sample Type
Serum, plasma samples
Research Areas
Hepatology; Toxicology
Datasheet