Accelerating Discovery with
Precision Science

In the rapidly evolving field of regenerative medicine, the quality of your cellular material dictates the success of your research. We move beyond standard protocols to offer adaptive, high-fidelity stem cell solutions.

Our approach combines rigorous biological characterization with advanced engineering. Whether you require footprint-free reprogramming, complex gene editing, or scalable differentiation, our scientific team serves as an extension of your laboratory, ensuring that every cell line we deliver meets the highest standards of phenotypic purity and genomic stability.

Custom Protocol Design
Rigorous QC Standards
Advanced Stem Cell Laboratory (Creative Biolabs Authorized)

10+ Years

Of experience in iPSC technology and differentiation

End-to-End Stem Cell Solutions

Whether you are in the discovery phase or moving towards IND-enabling studies, our modular service portfolio covers every aspect of stem cell biology.

iPSC Reprogramming & Editing

We generate footprint-free induced pluripotent stem cells (iPSCs) from PBMCs, fibroblasts, or urine-derived cells using episomal vectors or mRNA. Our CRISPR/Cas9 platform allows for precise gene correction, knock-in of reporter genes, or creation of isogenic disease models.

  • • Feeder-free & Xeno-free conditions
  • • SNP-array & Karyotyping QC
  • • High-efficiency homogenous editing
Learn More

Directed Differentiation

Transforming iPSCs/ESCs into high-purity somatic cells is our specialty. We offer robust protocols for neural lineages (dopaminergic neurons, astrocytes), cardiac cells (cardiomyocytes), hepatic cells, and immune effectors (NK cells, T cells, Macrophages).

  • • >95% Purity via cell sorting
  • • Functional maturation validation
  • • Scalable 3D suspension culture
Learn More

MSC & Exosome Services

Mesenchymal Stem Cells (MSCs) are pivotal for regenerative medicine. We provide isolation from various tissues (adipose, umbilical cord, bone marrow), expansion, and large-scale exosome purification. We characterize immunomodulatory properties and vesicle payload.

  • • Immunophenotyping (CD73/CD90/CD105)
  • • Potency assays (T-cell suppression)
  • • NTA & TEM Exosome Analysis
Learn More

Preclinical Safety Assays

Safety is the cornerstone of clinical translation. We conduct comprehensive biodistribution studies, tumorigenicity assays (in vivo teratoma formation), and soft agar colony formation assays to ensure your cell product is free of undifferentiated residual cells.

  • • GLP-compliant reporting standards
  • • Sensitive PCR-based biodistribution
  • • Long-term in vivo tracking
Learn More

Process Development

Transitioning from research grade to clinical grade requires strict process control. We optimize your protocol for closed-system manufacturing, establish Master Cell Banks (MCB), and validate reagents to meet stringent requirements, reducing time-to-market.

  • • SOP establishment & Validation
  • • Raw material qualification
  • • Stability testing programs
Learn More

3D Organoid Models

For disease modeling and drug screening, 2D cultures often fall short. We develop complex 3D organoids (Brain, Gut, Kidney, Liver) derived from iPSCs that recapitulate tissue architecture and physiology, providing a superior platform for efficacy testing.

  • • High-throughput screening compatible
  • • Patient-specific disease modeling
  • • Co-culture with immune cells
Learn More
Consult Our Scientific Team

Featured Technology Platforms

Leveraging advanced methodologies to overcome common hurdles in stem cell engineering, ensuring reproducibility and scalability.

High-Efficiency Gene Editing

Achieving clonal homogeneity in stem cells after gene editing is notoriously difficult. Our optimized protocols utilize anti-apoptotic factors during the sorting process, significantly enhancing single-cell survival rates.

Advantage: Rapid generation of homozygous knock-out or knock-in iPSC lines.

Patient-Specific Disease Modeling

We utilize patient-derived iPSCs differentiated into disease-relevant cell types (e.g., cardiomyocytes for cardiotoxicity) for high-content screening. This approach predicts human response better than traditional animal models.

Advantage: Early identification of toxic compounds and efficacy validation.

Automated Cell Expansion

Manual handling introduces variability. Our semi-automated culture systems standardize media changes and passaging for large-scale cell expansion, essential for generating the cell numbers required for master cell banks.

Advantage: Unmatched batch-to-batch consistency and scalability.

Non-Viral Delivery Systems

Transfecting stem cells without affecting pluripotency is challenging. We utilize advanced lipid-nanoparticle and electroporation protocols optimized specifically for fragile iPSCs and ESCs, ensuring high transfection efficiency with low toxicity.

Advantage: High viability preservation during genetic engineering.

The Creative Biolabs Advantage

Beyond standard services, we provide the strategic infrastructure and scientific stewardship needed for therapeutic success.

Traceability & Compliance

We don't just generate cells; we generate data packages. Every cell line is accompanied by rigorous documentation, including comprehensive COAs, sterility reports, and detailed batch records, ensuring full traceability for downstream regulatory submissions.

Technical Mastery

We specialize in the "difficult." From reprogramming senescent geriatric samples to editing recalcitrant loci in iPSCs, our PhD-led teams possess the nuanced expertise to succeed where standard protocols often fail.

Strategic Continuity

Eliminate vendor fragmentation. We offer a seamless continuum of services—from initial donor sourcing and reprogramming to gene editing, differentiation, and finally, bio-banking—streamlining your timeline and reducing variability.

Risk Mitigation

We proactively manage project risks. Through pilot studies, milestone-based checkpoints, and transparent "no-surprise" communication, we protect your budget and ensure you have full visibility into the scientific progress.

Start Your Project

Case Studies

Microscopy of cells (Creative Biolabs Authorized)
Case Study 01

Gene Modulation in Human iPSC-Cardiomyocytes

The Challenge

Achieving precise, time-resolved gene regulation in iPSC-derived cardiomyocytes.

The Solution

The combination of iPSCs and CRISPR-based gene editing, two scalable methods, has yielded high-throughput methods for gene screening, enabling the elucidation of the molecular basis of biological functions and the study of disease mechanisms.

The Outcome

The combination of these tools helps to reveal the complex system-level gene interactions that lead to specific phenotypes.

iPSC-neuron programming (Creative Biolabs Authorized)
Case Study 02

Generating a Unique Population of hiPSC-NSCs

The Challenge

Researchers explored iPSC-neuron programming using only NGN2 mRNA.

The Solution

They designed a neural programming method based on a single transcription factor, which uses NGN2 mRNA and utilizes a microfluidic environment to ensure efficient delivery of the mRNA.

The Outcome

Simultaneously targeting both the FGF2 and Notch signaling pathways can significantly increase the neuronal differentiation rate of hiPSCs.

View More Case Studies

References

  1. Han, Julie Leann, and Emilia Entcheva. "Gene modulation with CRISPR-based tools in human iPSC-cardiomyocytes." Stem cell reviews and reports 19.4 (2023): 886-905.https://doi.org/10.1007/s12015-023-10506-4
  2. Tolomeo, Anna Maria, et al. "NGN2 mmRNA-based transcriptional programming in microfluidic guides hiPSCs toward neural fate with multiple identities." Frontiers in Cellular Neuroscience 15 (2021): 602888.https://doi.org/10.3389/fncel.2021.602888
  3. Distributed under Open Access license CC BY 4.0, without modification.

Therapeutic Application Areas

Stem cells hold the key to treating degenerative diseases. We support development across major therapeutic verticals.

Neurodegenerative Diseases

We provide high-quality dopaminergic neurons for Parkinson's research, cortical neurons for Alzheimer's modeling, and motor neurons for ALS studies. Our services include electrophysiological characterization (MEA) to verify functional activity and network formation.

  • Modelling synaptic dysfunction
  • Blood-Brain Barrier (BBB) organoids
  • Neurotoxicity screening
Neural network staining (Creative Biolabs Authorized)

Workflow

A transparent, milestone-driven approach to ensure project success.

1

Consultation

Definition of project scope, cell type selection, and regulatory requirements assessment.

2

Development

Protocol optimization, reprogramming/editing, and pilot scale differentiation.

3

Validation

Rigorous QC: Flow cytometry, Karyotyping, Functional assays, and Sterility testing.

4

Delivery

Shipment of frozen cells, live cultures, or comprehensive data reports with COA.

Discuss Your Workflow

What Our Clients Say

“

Creative Biolabs solved a persistent differentiation issue we had with our specific patient lines. Their technical team not only optimized the protocol but provided detailed insights into why our previous attempts failed. The neurons they delivered were electrophysiologically active and robust.

Principal Investigator

Major Research University, USA

“

We engaged CBL for a complex gene-editing project involving a triple-knockout iPSC line. Their efficiency in generating single-cell clones and validating the off-target profile was impressive. It accelerated our timeline by at least 6 months.

CSO

Biotech Startup, Cambridge

“

The consistency of the MSCs provided for our inflammatory disease model was excellent. We needed large batches with specific marker expression profiles, and they delivered exactly to spec. The COA was very thorough.

Senior Scientist

Pharmaceutical Company, Germany

“

Reliable, communicative, and scientifically rigorous. We used their teratoma formation assay services for our IND submission, and the report quality met all regulatory expectations perfectly.

Regulatory Affairs Director

Cell Therapy Developer, Japan

Get Started with Confidence

Trusted by leading academic institutions and pharmaceutical companies worldwide.

AstraZeneca logo (Creative Biolabs Authorized) Novartis logo (Creative Biolabs Authorized) Sanofi logo (Creative Biolabs Authorized) GSK logo (Creative Biolabs Authorized) Pfizer logo (Creative Biolabs Authorized) Cold Spring Harbor Lab logo (Creative Biolabs Authorized) Cleveland Clinic logo (Creative Biolabs Authorized) AstraZeneca logo (Creative Biolabs Authorized) Novartis logo (Creative Biolabs Authorized) Sanofi logo (Creative Biolabs Authorized) GSK logo (Creative Biolabs Authorized) Pfizer logo (Creative Biolabs Authorized)

1. Initial Inquiry

Submit your project requirements via our online form or email.

2. Technical Discussion

Ph.D. level consultation to refine scope, timeline, and deliverables.

3. Project Execution

Regular updates while we perform the work in our state-of-the-art facilities.

Podcast

Stem Cells in a New Era of Cell-based Therapies

Join our experts as they discuss the latest breakthroughs in iPSC manufacturing and clinical applications.

Listen to Full Series

Frequently Asked Questions

Can you handle patient-derived samples that have low viability?
Yes, we have specialized recovery protocols for fragile patient samples. We recommend sending samples in our proprietary preservation media. Upon receipt, we perform an immediate viability assessment and, if necessary, use enrichment techniques to recover the target cell population before proceeding with reprogramming.
What quality control measures are included in your iPSC generation service?
Our standard QC package includes:
  • Morphological assessment
  • Immunocytochemistry for pluripotency markers (Oct4, Sox2, Nanog, Tra-1-60, Tra-1-81, SSEA-4)
  • Alkaline Phosphatase (AP) staining
  • Mycoplasma testing
  • Karyotyping (G-banding) to ensure genomic stability
Additional services like STR analysis and teratoma formation are available upon request.
Can you develop custom functional assays for my specific disease model?
Yes, we specialize in designing custom phenotypic assays tailored to your disease of interest. Whether it is measuring electrophysiological activity in neurons, contractility in cardiomyocytes, or cytokine release in immune cells, we can develop and validate a high-content screening assay to meet your research goals.
How long does the differentiation process take for specific lineages?
Timelines vary by lineage. Typically:
  • Neural progenitors: 3-4 weeks
  • Cardiomyocytes: 2-3 weeks
  • Mature Dopaminergic Neurons: 6-8 weeks
  • T-cells/NK-cells: 4-6 weeks
We provide a detailed Gantt chart at the beginning of every project.
Can you perform CRISPR editing on my existing iPSC line?
Absolutely. We can receive your established cell lines. We will first validate their pluripotency and karyotype to ensuring they are suitable for editing. We then perform the transfection, sorting, and screening for the desired edit.

Online Inquiry

For Research Use Only. Not For Clinical Use.