Therapeutic Target Discovery Services for Infectious Disease Research

The active search for therapeutic targets for infectious diseases is crucial for more effective treatment and enhanced control of these diseases. This process is complex and multi-stepped, fundamentally relying on a deep understanding of the pathogen's biological characteristics and its interaction mechanisms with the host. Effective intervention targeting these mechanisms can inhibit pathogen replication or lessen its damage to the host, thereby achieving treatment or prevention of the disease. Moreover, with the ongoing increase in pathogen variation and drug resistance, discovering new therapeutic targets is vital for maintaining the efficacy of existing treatments and addressing emerging infectious diseases. Creative Biolabs, with its extensive experience, cutting-edge technology, and highly educated professional team, is committed to supporting the discovery of key therapeutic targets for infectious diseases, contributing to global public health.

Fig.1 Workflow to search for cellular targets involved in virus–cell interactions.¹

Discovery Process and Key Points of Therapeutic Targets for Infectious Diseases

1. Pathogen identification and characteristic study.
2. Host response analysis: Understanding the immune response and physiological reactions of the host (such as humans) to pathogens. This includes identifying which host factors are exploited by the pathogen to infect and reproduce. For example, certain pathogens may use specific receptors or molecules of host cells to enter the cell and start their replication process. By understanding these processes, scientists can design drugs to prevent such behavior of the pathogen, thereby preventing disease progression.
3. Identification of key proteins and metabolic pathways: Finding key proteins and metabolic pathways on which the pathogen's survival and reproduction depend. These are often potential drug targets. Identifying these key proteins and pathways allows scientists to develop drugs that interfere with these processes, thereby inhibiting or killing the pathogen. For instance, antibiotics are often designed against bacterial-specific metabolic pathways or cell structures, while antiviral drugs might target specific viral replication enzymes or proteins.
4. Drug target validation.
5. Screening and optimization of candidate drugs.
6. Preclinical and clinical trials.

Particularly important in the above process are understanding the host's immune response and physiological reactions to the pathogen and identifying key proteins and metabolic pathways essential for the pathogen's survival and reproduction. Fortunately, with advancements in genomics, proteomics, and bioinformatics, the discovery of therapeutic targets for infectious diseases is becoming more efficient and precise.

Comprehensive Omics Services Assisting in Finding Therapeutic Targets for Infectious Diseases

Creative Biolabs, with its excellent omics services, has earned a prestigious position in the scientific exploration of finding therapeutic targets for infectious diseases. Our services not only comprehensively cover key areas such as genomics, proteomics, and transcriptomics but are also precise and efficient, providing clients with in-depth insights and customized solutions.

• Genomics: By analyzing the genome of pathogens, researchers can identify their genetic characteristics and variations, which helps in understanding their infection mechanisms and drug resistance. Similarly, analyzing the host's genome can reveal genetic factors affecting susceptibility to certain infectious diseases.
• Transcriptomics: Transcriptomics involves studying RNA molecules, especially mRNA expressed under specific conditions. By analyzing the transcriptomic changes in pathogens and host cells during infection, scientists can identify genes that play a key role in pathogen infection and reproduction.
• Proteomics: Proteomics focuses on the expression, modification, and interaction of proteins. By analyzing the protein expression patterns of both pathogens and host cells, researchers can identify key proteins and metabolic pathways as drug targets.
• Single-cell sequencing: Single-cell sequencing technology allows for the analysis of gene expression at the single-cell level. This is particularly important for understanding how immune cells individually respond to pathogens, as it can reveal heterogeneity and complex immune dynamics among cells.

Whether your goal is to develop innovative therapies, delve into pathogen research, or explore new areas of precision medicine, Creative Biolabs can be your ideal partner. Our team and services perfectly match your research needs, helping you achieve your goals. If you're looking for a trustworthy partner, feel free to contact us anytime.

Reference:

1. Roa-Linares, VC.; et al. Host cell targets for unconventional antivirals against RNA viruses. Viruses. 2023, 15(3).

Related Sections

• Mechanism Investigation Services for Virus Infection
• Mechanism Investigation Services for Bacteria Infection