Non-Pharmaceutical Grade Hit Characterization Services for Bacteria Infection Research

The treatment research for infections is facing unprecedented challenges. The development of new antimicrobial drugs has become a top priority in the field of public health. Creative Biolabs is dedicated to providing clients with comprehensive candidate drug characterization services, aiming to facilitate the development of bacterial infection treatment research. We understand the importance of candidate drug characterization in ensuring the success of drug development. Therefore, we offer functional assessment services and research services to ensure each candidate drug reaches its optimal potential.

Fig.1 Conventional phenotypic antimicrobial susceptibility testing methods.¹

Importance of Candidate Drug Characterization

• Assessing Potential Efficacy: Candidate drug characterization helps researchers evaluate the potential efficacy of drugs in vitro, which is a crucial step in determining their effectiveness in in vivo models.
• Developing Dosage Schemes: Characterization of candidate drugs provides key data for developing optimal dosage schemes, ensuring the drug's effectiveness and safety in practical use.
• Quantifying Drug Effects: Standardized analytical methods enable researchers to precisely quantify the impact of candidate drugs on bacterial growth and infectiousness, thereby better understanding the drug's mechanism of action.
• Identifying Key Drug Parameters: Calculating parameters such as Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC), and time-kill values, which are critical indicators for assessing the potency of antimicrobial drugs.
• Supporting Cell-Based Tests: This includes studies on drug internalization, killing, and effects on biofilms, providing detailed information about the interactions between drugs and bacteria.

Development of Novel Antimicrobial Peptides

In the ongoing progress of infectious disease treatment research, antimicrobial peptides, as an emerging type of antimicrobial drug, show great potential. Creative Biolabs is at the forefront of offering comprehensive antibody/peptide discovery services, focusing on supporting clients' needs in the screening and development of antimicrobial peptides.

Fig.2 Conventional phenotypic antimicrobial susceptibility testing methods.²

By combining the latest technology with deep expertise, we are committed to providing clients with a full range of services from early screening to drug development, including but not limited to:

• High-throughput screening of antimicrobial peptides
• Activity verification
• Mechanism of action studies
• Pharmacological evaluation

Our goal is to help clients quickly and accurately discover and develop effective antimicrobial peptides, contributing new solutions to the treatment of infectious diseases.

Core Services in Drug Characterization

To fully meet our clients' research needs, we at Creative Biolabs have introduced three core services to explore and optimize the immense potential of candidate drugs:

• Bactericidal and Bacteriostatic Efficacy Evaluation Service: By precisely measuring parameters like MIC and MBC, we assist clients in comprehensively assessing the inhibitory or bactericidal effects of candidate drugs on specific bacteria. This provides not only key data on drug potency but also guides future clinical application strategies.
• Mechanism Investigation Services: Our team, using advanced technology, offers in-depth analysis of the mechanisms by which candidate drugs resist bacterial infections. This service aims to reveal the principles of drug action and their interactions with microbes, providing a scientific basis for optimizing drug design and development strategies.
• Biofilm Test Service: The formation of biofilms is a key factor in many bacterial infections, especially in the face of increasing antibiotic resistance. Our biofilm testing service specifically evaluates the ability of candidate drugs to inhibit or disrupt biofilms, which is significant for developing new treatment strategies against stubborn bacterial infections.

Creative Biolabs has a professional team consisting of microbiologists, medicinal chemists, and bioengineers. Our team members have extensive experience in various stages of antimicrobial drug development, especially in testing antimicrobial drug efficacy. If you are seeking professional support in characterizing your screened candidate drugs and wish to utilize expertise to optimize their activity, please contact us. We look forward to collaborating with you to advance your antimicrobial drug development project.

References:

1. Salam, MA. et al. Conventional methods and future trends in antimicrobial susceptibility testing. Saudi Journal Of Biological Sciences. 2023, 30(3):103582.
2. Luo, Y. Song, Y. Mechanism of antimicrobial peptides: antimicrobial, anti-inflammatory and antibiofilm activities. International Journal of Molecular Sciences. 2021, 22(21).

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