Phage Discovery Service for Drug-resistant Bacteria Infection Research

In today's medical field, the threat of drug-resistant bacteria is increasingly severe, posing a serious challenge to public health. To address this challenge, Creative Biolabs is actively engaged in phage discovery and engineering research, offering advanced phage discovery services to support global researchers and medical experts in breakthroughs in the treatment of drug-resistant bacterial infections.

Challenges of Drug-Resistant Bacterial Infections

• Reduced antibiotic efficacy: Enhanced resistance of drug-resistant bacteria to existing antibiotics leads to decreased effectiveness of common treatments.
• Limited treatment options: Increased resistance limits effective treatment choices, posing greater challenges for doctors in treating these infections.
• Increased serious health risks: Drug-resistant bacterial infections can lead to more severe health issues, such as persistent infections, recurrence, or fatal diseases.
• Challenges in new drug development: Developing alternative treatment methods, such as phage therapy, faces scientific and technological challenges.

Phage Therapy Strategies for Drug-Resistant Bacterial Infections

Phage therapy, as an innovative strategy, shows immense potential in addressing the growing issue of drug-resistant bacterial infections.

• High specificity: Phages can specifically identify and infect certain bacteria, meaning they can precisely target drug-resistant bacteria without affecting beneficial bacteria in the human body.
• Self-limiting proliferation: Phages only proliferate in the presence of their host bacteria and naturally decrease in number once the bacteria are eliminated, reducing potential risks to the host.
• Reducing resistance development: Using phages can reduce dependence on traditional antibiotics, thus helping to slow down the development of resistance.
• Engineering and customization: Through genetic engineering, phages can be customized and optimized to enhance their effectiveness against specific drug-resistant bacteria.
• Strategic flexibility: Phages can be used alone or in conjunction with antibiotics, providing more options and flexibility in treatment.
• Addressing severe infections: For severe infections that have developed resistance to multiple antibiotics, phage therapy offers a potential effective solution.

Recent research findings reveal the potential of phage therapy strategies in combating drug-resistant bacterial infections:

1. Lung infection caused by carbapenem-resistant Acinetobacter baumannii (CRAB): An 88-year-old Chinese male with chronic obstructive pulmonary disease, infected with CRAB, leading to hospital-acquired pneumonia. The patient received an innovative treatment of a customized phage preparation for this pathogen, administered via nebulization for 16 days, along with conventional antibiotics. This combined treatment method successfully cleared the pathogen and significantly improved the patient's lung function.

Fig.1 Patient clinical data in phage therapy.¹

2. Empyema caused by carbapenem-resistant Pseudomonas aeruginosa: A 68-year-old Chinese male, after lung resection surgery, suffered from bronchopleural fistula-related empyema caused by carbapenem-resistant Pseudomonas aeruginosa, a highly fatal infection. The patient underwent a treatment of two phage preparations targeting this pathogen, administered for 24 days, along with traditional antibiotics. This combined treatment strategy effectively cleared the pathogen and significantly improved the patient's clinical condition.

Fig.2 Graph of bacterial cultures, inflammatory markers, and the duration of antibiotic and bacteriophage administration.²

These two cases demonstrate the tremendous therapeutic potential of personalized phage therapy in addressing complex drug-resistant bacterial infections, providing new directions for future antimicrobial strategies.

Phage Engineering Services at Creative Biolabs

Creative Biolabs offers cutting-edge biotechnological services in phage engineering, focusing on using phages to combat drug-resistant bacterial infections. Our range of services encompasses, among others:

• Phage screening and identification: High-throughput screening of specific phages from diverse samples.
• Genome editing and modification: Using advanced gene editing technologies to specifically modify phages, enhancing their specificity and bactericidal efficiency against certain drug-resistant bacteria.
• Functional assessment: Evaluating the infection and killing effects of modified phages on specific drug-resistant bacteria.
• Customized phage development: Designing and constructing engineered phages specifically targeting certain drug-resistant bacteria based on client needs.

If you are seeking to develop and utilize the immense potential of phages in combating drug-resistant bacteria, Creative Biolabs is ready to provide you with professional technical services. Our team, with extensive experience and advanced technology, is committed to helping you achieve significant breakthroughs in this frontier field. Please feel free to contact us, and we look forward to exploring the limitless possibilities of phage therapy with you.

References:

1. Tan, X. et al. Clinical experience of personalized phage therapy against carbapenem-resistant Acinetobacter baumannii lung infection in a patient with chronic obstructive pulmonary disease. Frontiers in Cellular and Infection Microbiology. 2021, 11:631585.
2. Chen, P. et al. Bacteriophage therapy for empyema caused by carbapenem-resistant Pseudomonas aeruginosa. BioScience Trends. 2022, 16(2):158-162.

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