In a recent study, researchers from the University of Illinois Urbana-Champaign in the United States have discovered that CAR-T cell immunotherapy could potentially be a highly effective treatment for solid tumors ifRead More…
The Loss of Metabolic Adaptability Reveals a Key Mechanism of Tumor Resistance in CAR-NK Cells
In a recent study conducted by researchers from institutions including the MD Anderson Cancer Center at the University of Texas, USA, it has been discovered that the loss of metabolic capacity inRead More…
A Revolutionary CAR-T Therapy with Potential for Blood Cancer Treatment
Immunotherapy strategies aim to utilize the patient’s own immune system cells to eliminate tumor cells. CAR-T cell therapy is an effective treatment for human blood cancers. In France, approximately 35,000 people areRead More…
An Improved Form of CAR-T Cell Therapy Shows Potential for Treating Myasthenia Gravis
A small-scale clinical trial suggests that an improved form of CAR-T cell therapy, known as Descartes-08, holds promise for treating myasthenia gravis, an autoimmune neuromuscular disease. The modified CAR-T therapy used inRead More…
HER2-targeting CAR-T Cells Show Promise for Show Promise for Diffuse Intrinsic Pontine Glioma
Diffuse Intrinsic Pontine Glioma (DIPG) is an aggressive brain tumor that usually occurs in children between 5 and 7. This fast-growing tumor forms in the part of a child’s brain responsible forRead More…
Gut Microbiome Plays a Key Role in CAR-T Cell Cancer Immunotherapy
In a recent study, researchers from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), the Weizmann Institute of Science in Israel, the University of South Florida, and the University of Texas MDRead More…
Knockdown of Two Genes by CRISPR-Cas9 to Improve T-Cell Therapy in Solid Tumors
Since the world’s first chimeric antigen receptor (CAR)-T cell therapy was approved for marketing in 2017, the Food and Drug Administration (FDA) has approved a total of six CAR-T cell therapies toRead More…
Overcoming On-Target Off-Tumor Toxicity of CAR T-Cell Therapy for Solid Tumors
The success of CAR T cells in treating hematologic malignancies has provided impetus for the development of CAR T therapies in solid tumors. The biggest obstacle to the development of CAR TRead More…
Personalized Stimulation on CAR-T Cells During Manufacture Promises to Make Personalized CAR-T Cell Therapy A Reality
Since 2017, when chimeric antigen receptor-T cells (CAR-T) were approved by the US Food and Drug Administration (FDA) as the first modified cell for the treatment of leukemia, five similar products haveRead More…
Dual-Target CAR-T Cell Therapy Is Driving Next Wave of Innovation in Immunotherapy
Chimeric antigen receptor (CAR) T cells have been remarkably successful in the treatment of relapsed hematologic malignancies, such as acute lymphoblastic leukemia (ALL), non-Hodgkin’s lymphoma (NHL), and multiple myeloma (MM). CD19 andRead More…
