Exosomes are secretory vesicles with a diameter of about 30 to 150 nanometers that play an important role in human health and disease. To better understand how cells release these vesicles, researchersRead More…
28May/24
28Apr/24
The Regulatory Role and Therapeutic Potential of Peripherally Derived Extracellular Vesicles in Neurodegenerative Diseases
Neurodegenerative diseases (NDDs), such as Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis, constitute a class of progressive diseases with complex pathogenesis. Traditional treatments face significant challenges due to drug delivery challenges.Read More…
28Mar/24
Extracellular Vesicles as Biomarkers for Detection and Therapeutic Applications
Extracellular vesicles (EVs) secreted by all cell types are involved in the intercellular communication, delivering regulatory factors that influence cell and tissue phenotypes in both normal and diseased tissues. Therefore, EVs representRead More…
29Feb/24
Extracellular Vesicles Incorporate Retrovirus-Like Capsids for Enhanced Packaging and Systemic Delivery of mRNA to Neurons
The blood-brain barrier (BBB) poses a significant challenge to the systemic delivery of mRNA to diseased neurons.While extracellular vesicles (EVs) derived from leukocytes can traverse the BBB, efficiently loading lengthy mRNAs intoRead More…
28Jan/24
Self-Stimulating Release Hydrogel Enhances the Therapeutic Effect of MSC-EVs on Alzheimer’s Disease
Extracellular vesicle (EV)-based therapeutic approaches still pose challenges in clinical application due to their rapid clearance, limited residence, and low yield. Although hydrogels possess the ability to impede physiological clearance and increaseRead More…
28Dec/23
Entry and Exit of Extracellular Vesicles into and from the Blood Circulation
Extracellular vesicles (EVs) are biological nanoparticles that mediate short- and long-distance intercellular communication, delivering bioactive payloads. Short-distance communication occurs in the interstitium, while long-distance communication necessitates transport through the blood circulation toRead More…
28Nov/23
Vesiclepedia 2024 – Extracellular Vesicles and Particles Database Update
Vesiclepedia (http://www.microvesicles.org) stands as a comprehensive, web-based database, offering a compilation of DNA, RNA, proteins, lipids, and metabolites that have been identified or associated with extracellular vesicles (EVs) and extracellular particles (EPs).Read More…
28Oct/23
Creating Designer Engineered Extracellular Vesicles for Diverse Ligand Display, Target Recognition, and Controlled Protein Loading and Delivery
Effective and targeted drug delivery remains a significant challenge in modern medicine. Researchers are employing biochemical engineering approaches to repurpose extracellular vesicles (EVs) as drug delivery vehicles. Studies have demonstrated that displayingRead More…
28Sep/23
Therapeutic Potential in Rheumatic Diseases of Extracellular Vesicles Derived from Mesenchymal Stromal Cells
A recent review was published in Nature Reviews Rheumatology delves into the promising therapeutic applications of mesenchymal stromal cell extracellular vesicles (EVs) in rheumatic diseases. Rheumatic diseases comprise a diverse range ofRead More…
28Aug/23
Identifying of Scaffold Proteins to Enhance Endogenous Engineering of Extracellular Vesicles
Extracellular vesicles (EVs) have emerged as a promising avenue for advanced drug delivery. One effective strategy for loading these EVs with desired cargo involves genetically fusing a target protein to a scaffoldRead More…