Extracellular vesicles (EVs) secreted by all cell types are involved in the intercellular communication, delivering regulatory factors that influence cell and tissue phenotypes in both normal and diseased tissues. Therefore, EVs representRead More…
The blood-brain barrier (BBB) poses a significant challenge to the systemic delivery of mRNA to diseased neurons.While extracellular vesicles (EVs) derived from leukocytes can traverse the BBB, efficiently loading lengthy mRNAs intoRead More…
Extracellular vesicle (EV)-based therapeutic approaches still pose challenges in clinical application due to their rapid clearance, limited residence, and low yield. Although hydrogels possess the ability to impede physiological clearance and increaseRead More…
Extracellular vesicles (EVs) are biological nanoparticles that mediate short- and long-distance intercellular communication, delivering bioactive payloads. Short-distance communication occurs in the interstitium, while long-distance communication necessitates transport through the blood circulation toRead More…
Vesiclepedia (http://www.microvesicles.org) stands as a comprehensive, web-based database, offering a compilation of DNA, RNA, proteins, lipids, and metabolites that have been identified or associated with extracellular vesicles (EVs) and extracellular particles (EPs).Read More…
Effective and targeted drug delivery remains a significant challenge in modern medicine. Researchers are employing biochemical engineering approaches to repurpose extracellular vesicles (EVs) as drug delivery vehicles. Studies have demonstrated that displayingRead More…
A recent review was published in Nature Reviews Rheumatology delves into the promising therapeutic applications of mesenchymal stromal cell extracellular vesicles (EVs) in rheumatic diseases. Rheumatic diseases comprise a diverse range ofRead More…
Extracellular vesicles (EVs) have emerged as a promising avenue for advanced drug delivery. One effective strategy for loading these EVs with desired cargo involves genetically fusing a target protein to a scaffoldRead More…
Systems featuring programmable RNA molecule export capabilities hold the potential for non-destructive cellular dynamics monitoring and efficient RNA delivery to engineered cells. In a recent breakthrough, Michael B. Elowitz and Felix HornsRead More…
Recent studies have revealed that extracellular vesicles (EVs) surface molecules are often accompanied by glycan or glycosylation modifications. Researchers from the Institute of Chemistry at the Slovak National Academy of Sciences haveRead More…