With our Professional competence in functional analysis of neoantigen-specific TCR, Creative Biolabs has developed a comprehensive platform for neoantigen-based cancer immunotherapy development.

Introduction of Neoantigen-specific TCR

In contrast with conventional TCRs, as shown in Fig.1, TCR-like CARs or TCR-CARs based on neoantigens have the advantages of both TCRs and CARs. TCR-like CARs and TCR-CARs with a scFv targeting neoantigens could specifically target the tumor site and could be rapidly activated to offer robust and long-term protection. Creative Biolabs has established a comprehensive platform for the functional analysis of neoantigen-specific TCR.

Fig.1 Advantages of Neoantigen-based TCR-like CAR or TCR-CAR.¹

One-Stop Workflow for Functional Analysis of Neoantigen-specific TCR

Functional analysis of neoantigen-specific TCR is a routine program operated by a team of experts. With accumulated successful experiences, we could fulfill specific project requirements with quick responses. The typical workflow for our neoantigen-specific TCR analysis is shown in Fig.2.

Fig.2 Experimental workflow for functional analysis of neoantigen-specific TCR.

Key Features

• Quick responses with a short timeline
• High transduction efficiency to ensure cellular functional analysis
• Comprehensive assessment routinely executed with a team of experts
• Multi-dimensional analysis of the specificity, avidity, and longevity of neoantigen-specific TCRs
• Professional data analysis with visual interpretation

Neoantigen-based immunotherapy has become a novel and ideal strategy for cancer treatment. For the advantages of neoantigen-specific TCR-like CARs and TCR-CARs, Creative Biolabs already has a professional and well-established platform to help our clients with the functional assessment of neoantigen-specific TCRs.

Reference

1. Poorebrahim, Mansour, et al. "TCR-like CARs and TCR-CARs targeting neoepitopes: An emerging potential." Cancer gene therapy 28.6 (2021): 581-589. Distributed under Open Access license CC BY 4.0, without modification.

For Research Use Only | Not For Clinical Use