Increasing the immunogenicity of cancer cells through the induction of immunogenic cell death (ICD) is emerging as an effective way to boost the efficacy of cancer immunotherapy. Despite its success with certain types of cancer, immunotherapy has unfortunately shown limited responsiveness in many kinds of solid tumors. Using ICD inducers to stimulate a specific immune response, however, could prove to be a significant breakthrough in cancer treatment.
Fig.1 The mechanism of ICD induced by lionizing radiation.1
When ICD inducers are included in an appropriate microenvironment, they have the ability to increase the immunogenic of tumor cells to stimulate the immune system and initiate targeted immune responses. Creative Biolabs provides an immunogenic cell death inducer development service for cancer immunotherapy that focuses on developing various ICD inducers for enhancing cancer immunotherapy. We provide a wide range of developing services targeting various ICD inducers such as microbial, chemical, and physical. Every inducer has its unique properties, thus we simultaneously custom-develop solutions to support global customers' diverse projects. In addition, we also supply multiple types of ICD biomarkers and related detection methods to give convenience in examining inducers' effectiveness and screening the most effective inducer. Together with our robust development platform and experienced research team, we have great confidence in answering every customer with a high-quality outcome.
Fig.2 The activation of the adaptive immune system after the tumor's ICD.2
| Promising Inducers | Types | Promising Inducers | Types |
|---|---|---|---|
| Microbial ICD inducer | Obligate intracellular pathogens, Oncolytic virus | Chemotherapeutic ICD inducers (CT) | Non-metallic chemotherapeutic agents |
| Photodynamic therapeutic ICD inducer (PDT) | Metallic chemotherapeutic agents, Organic photosensitizers, Inorganic photosensitizers, Organic-inorganic hybrid materials | Photothermal therapeutic ICD inducer (PTT) | Organic photosensitizers, inorganic photosensitizers, and organic-inorganic hybrid materials |
| Radiation therapeutic ICD inducer (RT) | X-ray, radioisotopes | Synergistic therapeutic ICD inducer (Syn-T) | |
| Magnetic hyperthermia therapeutic ICD inducer (MHT) | Sonodynamic therapeutic ICD inducer (SDT) |
Fig.3 Hot ICD biomarkers for inducer development.
Various detection methods possess their unique application ranges. To effectively verify and screen the desirable inducers, we provide a set of well-developed ICD biomarkers detection approaches to advance global customers' ICD inducer development projects:
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As a leading company in cancer immunotherapy development, Creative Biolabs is dedicated to discovering effective approaches to aid in cancer treatment. If you want to know more details about our immunogenic cell death inducer development service for cancer immunotherapy, please don't hesitate to contact us.
References
For Research Use Only | Not For Clinical Use
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