Short Description
Measures uricase activity via uric acid oxidation.
Development Stage
Research-Grade Protein & Enzyme Assay Development
Description
The ModifiSite™ Uricase Assay Kit employs a UV kinetic assay to validate recombinant uricase potency for the treatment of refractory gout. This assay measures the enzymatic degradation of uric acid, supporting the development of biologics for hyperuricemia. It ensures the specific activity and stability of therapeutic enzymes in pharmaceutical formulations.
Features
UV kinetic assay; Validates recombinant uricase potency for refractory gout treatment.
Process Relevance
Biologic Therapeutic Development
Application Stage
CMC / Manufacturing
Applications
Gout therapy development (uricase drugs).
Qualified With
Internal performance validation using reference standards under defined assay conditions.
Detection Method
Fluorescence Detection (Ex 530 nm / Em 585 nm)
Sample Type
Serum, citrate-plasma, urine, cell lysate, culture medium
Research Areas
Rheumatology; Biotherapeutics
Datasheet