Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
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EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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EXPLORE MOREAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
Synthetic Notch (synNotch) is an ingenious CAR design, which can achieve "antigen A AND antigen B" combinatorial antigen recognition. The design strategy is that the synthetic Notch receptor for one antigen (antigen B) induces the expression of a CAR for a second antigen (antigen A). Thus, the "AND-gate" CAR T cells have a combinatorial antigen recognition circuit working in a sequential manner: the constitutively expressed synthetic Notch (synNotch) receptor first binds with antigen B and then induces CAR molecule expression to recognize antigen. "ANDgate CAR T" cells with the synNotch receptor have the same anti-tumor efficacy as regular CAR T cells, with much higher target cell discrimination. Moreover, the synNotch receptors can also be used to sculpt custom-response programs in primary T cells: they can drive a la carte cytokine secretion profiles, biased T cell differentiation, and local delivery of non-native therapeutic payloads in response to antigen.
There are currently no customer reviews or questions for Anti-B7-H3 (Myc-scFv-Notch Core-TF), with Anti-ROR1 (scFv-CD28-CD3ζ ) CAR, A SynNotch CAR System (CAR-NR-ZP2497). Click the button below to contact us or submit your feedback about this product.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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