CAR-MA Vector Products

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

As a world-renowned service provider for immune therapy, Creative Biolabs has successfully established genetic engineering CAR-Macrophage (CAR-MA), aiming to improve the ability of CAR cells to attack solid tumors. CAR-MA displays superior homing capacities to solid tumor sites and may better maintain anti-tumor activity in the tumor microenvironment as compared with CAR-T cells, which can lead to enhanced tumor reduction. CAR-MA can interact with almost all cellular components in the tumor microenvironment such as T-cells to enhance anti-tumor activity.

Mechanism of CAR-MA

CAR-MA is activated by tumor-associated antigen engagement with the CAR, signaling via CD3-ζ and other signaling domains to phagocytose the tumor cell and release cytokines and chemokines that 'warm up' the tumor microenvironment. Virally transduced CAR-MA are locked into a pro-inflammatory M1 phenotype during the manufacturing process. They produce locally acting mediators that reprogram the tumor microenvironment, drawing in T and natural killer (NK) cells, activating nearby APCs, notably dendritic cells (DCs), and repolarizing TAMs toward an M1 phenotype. In addition to direct phagocytosis of tumor cells, CAR-MA presents a patient's unique array of neoantigens to T cells, leading to a broad adaptive immune response that has the potential to generate long-term immunity beyond the antigen targeted by the CAR.

Closer insight into CAR-MA activation and anti-cancer mechanisms. Figure 1. Closer insight into CAR-MA activation and anti-cancer mechanisms. (Abdin, 2021)

CARMA Vector Construction Service and Products

Creative Biolabs is a leader in the field of genetically engineered macrophage cells for cancer treatment, providing gene transduction system service for the generation of CAR-MA. With our advanced technology and rich experience, we provide the most professional carrier service for cutting-edge transgenic immunotherapy. We offer both virus vector system and non-virus vector system.

Virus vector system
Retrovirus vectors and lentivirus vectors are utilized to facilitate the stable and efficient expression of the target gene in the target cells, which shows high efficiency of transduction.
Non-virus vector system
The vector offers transposons, Sleeping Beauty and PiggyBac, they provide potential for convenient and quick research for clinical application in the later stage.

In addtion to CAR-MA vectors, we also provide One-Stop CAR-MA Therapy Development service.

Please feel free to contact us if you are interested in our following provided CARMA vector products. If the vector of interest is not available in our product list, please send us an inquiry and our scientist will provide assistance to offer a custom-made CARMA vector for you.

Reference

Abdin, Shifaa M., et al. "CARs and beyond: tailoring macrophage-based cell therapeutics to combat solid malignancies." Journal for Immunotherapy of Cancer 9.8 (2021).

We have developed a proprietary online system for customizing CAR and CAR cell products, which offers full options to meet all unique needs, including but not limited to conventional or unconventional CAR constructs, as well as a variety of vectors and cells. The customization process can be completed with just a few simple clicks, please feel free to try it out.

Associated Antigen Target