CONTACT US
45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-871-5806
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Email:

One-Stop CAR-T Therapy Development Services

Immunotherapy has become a revolution in the area of cancer treatment. Compared to the traditional methods, such as invasive surgeries, radiation and chemotherapy, immunotherapy is more specific and less toxic to patients. Chimeric antigen receptor (CAR)-engineered T cell therapy is the most promising approach, which has shown remarkable ability to eliminate various kinds of tumors, especially for B cell malignancies, with up to 95% response rates and durable complete remission. A CAR mainly consists of a single chain variable fragment (scFv) from a monoclonal antibody which binds a specific antigen, a hinge and spacer element, a trans-membrane region and an internal signaling domain such as CD3ζ. The main advantage of CAR-T cell is that it bypasses MHC restriction, which allows for direct activation of effector cells for the treatment of various types of tumors.

Creative Biolabs is a world-renowned service provider for immunotherapy. We have one of the world’s largest collection of CAR products of different generations targeting various biomarkers, and we continue to innovate the next generation CAR technologies to achieve even greater results. Based on advanced technology and years of research, Creative Biolabs offers high-quality custom service covering the entire CAR-T therapy development process to best suit your technical, program and budget requirements which can greatly assist your research, preclinical investigation and clinical stage development.

Our one-stop CAR-T therapy development services include but not limited to:

Biomarker Identification & Selection
Biomarker Identification & Selection
  • De novo discovery of potential cancer biomarkers by multiple gene and protein analysis technologies
  • Selection of the most suitable CAR-T therapy targets with greater potency and lower toxicity
High Affinity ScFv Generation
High Affinity ScFv Generation
  • In-house inescapable antibody sequence data base
  • A collection of over 6000 antibody products
  • Antibody discovery by hybridomas, mouse, rabbit and human library
  • ScFv sequencing and NGS of hybridomas or phage libary
  • ScFv affinity measurement and optimization
CAR Design & Construction
CAR Design & Construction
  • Design and construction of CARs of different generation
  • SmartTM CAR platform for the next generation CAR discovery
  • Customized lentiviral or retroviral CAR construction
Virus Packaging & CAR Gene Delivery
Virus Packaging & CAR Gene Delivery
  • High titer transduction-ready pseudoviral particles produced by our cell manufacture platform
  • GMP virus manufacturing for clinical trials and applications
  • Strict quality control
  • Various transfection technology available
  • Transfection method tailored for different cell types
CAR T in Vitro Assay
CAR-T In Vitro Assay
  • CAR expression validation
  • CAR-T cell proliferation
  • Multiplex cytokine screening
  • Cytotoxicity test against target cells
CAR T Preclinical in Vivo Assay
CAR-T Preclinical In Vivo Assay
  • Construction of Xenograft Animal Model
  • Efficacy Test of CAR-T cells
  • Viability and Bio-distribution Study of CAR-T cells
  • Toxicity Evaluation of CAR-T cells
  • GLP-compliant assays
CAR T Clinical Trail
CAR-T Clinical Trail
  • Study design and filing
  • Project management and execution
  • Data management and biostatistics
  • QA&QC

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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

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