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EXPLORE MORECreative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsTo accelerate advanced breakthroughs of your projects, we offer broad range of platforms which enable our clients be free to tackle problems with cutting-edge technologies from different angles and in different methods.
EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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Chimeric antigen receptor (CAR) T cell immunotherapy has produced remarkable clinical outcomes in the treatment of leukemia and lymphoma, but the effectiveness is limited for solid tumors. Gene silence elements, such as microRNA (miRNA) or short-hairpin RNA (shRNA), are able to silence transcripts, providing a way to overcome some of the challenges in CAR-T therapy. At Creative Biolabs, we have developed a novel next-generation strategy to enhance the effector function of CAR-T cells by co-expression of a CAR gene with gene silence elements. The strategy aims to engineer T-cells with specific desired features by the modulation of gene expression in a CAR construct.
Fig.1 Silence™ CAR-T cell platform.
As the leader in CAR-T therapies, Creative Biolabs combines the CAR-T platform with gene silence technologies to develop next-generation strategies for advances in CAR-T therapy. We carry out a novel method in which miRNA or shRNA cassettes are integrated into a single CAR-expressing vector.
Silence™ CAR is a novel platform to enhance CAR T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality. The following are some potential strategies for the genetic modification of CAR T cells.
We have built in-house expertise in the latest technologies to facilitate development of the novel CAR T cells.
For detailed technical information, pricing, turnaround time, or a quotation for custom services, please contact us.
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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