Immune Monitoring Platform

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Effective Immune monitoring will bring a more complete understanding of the mechanisms, which will open the door to new and better targeted therapeutic interventions aiming at the immune response in the desired direction. The development of reliable techniques that could allow the quantitation and characterization of immune responses have always been important in clinical studies.

Creative Biolabs has organized a staff of highly experienced scientists who have engaged in Immune monitoring research for many years. Our R&D scientific team has designed and conducted many Immune Biomarker Development projects during the past few years. Many years of experience have led to a large number of successes. To enable innovative biomarker development for Immune monitoring, we offer highly customized solutions.

Immune Monitoring: Essential for Therapeutics Development

Immunotherapy with therapeutics aims specifically at inducing tumor antigen-specific T cells. The immune system is a complex, multifaceted cellular network, which is not fully understood. Monitoring cellular immune response is essential for rational cancer therapeutics development. The primary objectives of immune monitoring after treating with therapeutics are to document the induction of therapeutics-specific immune responses and to correlate the presence and magnitude of therapeutics-induced immune responses to clinical outcomes. Immune monitoring could also be applied to:

Defining the ability of a given therapeutics to generate antigen cascade responses.
Comparing the effects of therapeutics of different potencies.
Evaluating the ability of a given cytokine, drug, or adjuvant to enhance or hinder therapeutics-induced immune responses.
Defining appropriate patient populations for therapeutics studies.
Studying the presence and activity of inhibitory/suppressor cell populations.

Immune Monitoring Platform

Exploration of Oncology Biomarkers for Immune Monitoring at Creative Biolabs

Creative Biolabs has established a cutting-edge Immune monitoring platform to characterize the immune responses in the treatment of many diseases, especially cancers. Sensitive, accurate, and specific Immune monitoring has wide applications in cancer research. We offer high-quality services for a comprehensive list of biomarkers, including Prognostic Biomarkers, Predictive Biomarkers, Pharmacodynamic (PD) Biomarkers, Pharmacokinetic (PK) Biomarkers, and Correlative/Surrogate Endpoint Biomarkers. By the detection of these meaningful biomarkers, we will document whether the treatment has its desired effect on immune cell activation.

Our seasoned scientists have developed a portfolio of Technologies for Immune Monitoring designed to help researchers in the discovery of biomarkers for immune monitoring. Our techniques will lead, at least, to a better understanding of how and when the response occurs. These include Immunoscore Assay, Protein Microarray, Gene Expression Microarray, RNA Sequencing (RNA-seq), ctDNA Analysis, Microsatellite Instability (MSI) Analysis, T Cell Receptor (TCR) Repertoire Analysis, High-throughput Single-nucleotide Polymorphism (SNP) Genotyping, Tumor Mutational Burden (TMB) Biomarker Discovery, Tumor Neoantigen Analysis, Enzyme-linked Immunosorbent Assay (ELISA) for Immune Monitoring, Enzyme-linked Immunosorbent Spot (ELISpot) Assay, Flow Cytometry, Multiplex Immunohistochemistry (IHC) Assay, Neutrophil-to-lymphocyte Ratio (NLR) Analysis, and Mass Spectrometric Imaging (MSI). Moreover, we also provide high-quality In Silico Biomarker Discovery by applying a novel methodology that would enable a comprehensive analysis of a body of information on biomarkers.

Immune Monitoring Platform 1

Creative Biolabs is well equipped and versed in biomarker development for immune monitoring. We are glad to serve our global clients with professionalism and expertise in this field. For more detailed information, please feel free to contact us or directly send us an inquiry.

Reference

Hernandez-Fuentes, M.P. et al. Immune monitoring. Immuneal reviews. 2003, 196(1):247-64.