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The TRAV1-2-TCRs (MAV14, MAV21, and MAV36) all bound MR1 tetramer in an Ag-dependent manner and, similar to the TRAV1-2+ TCRs, variable Ag recognition was observed. For example, MAV36 was clearly dependent on the presence of 5-OP-RU but not 6-FP or Ac-6-FP, whereas MAV14 bound to MR1 tetramers loaded with 5-OP-RU, 6-FP, and Ac-6-FP, albeit to varying degrees. The MAV21 weakly bound to human MR1-5-OP-RU tetramer and did not bind mouse MR1-5-OP-RU tetramer. However, MAV21 bound human MR1 6-FP and Ac-6-FP tetramers with high intensity, highlighting that this TRAV1-2- TCR selectively detects folate-derivative ligands.
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