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The vector of anti-CD37 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human CD37. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CD37 antibody linked to 41BB and CD3ζ signaling domains. And the vector product was designed for the treatment of Mature B cell neoplasms,non-Hodgkin lymphoma (NHL).
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CAR Construction :
Fig.1 CD37 Antibody Clone 2B8D12F2D4 Binds Specifically and Selectively with High Affinity to CD37 Antigen. Surface plasmon resonance kinetic data collected on Biacore with anti-CD37 2B8 antibody bound to mouse capture chip and titration of CD37-His. KD of 1.65 nm was measured from two independent experiments. Golubovskaya, V., Zhou, H., Li, F., Valentine, M., Sun, J., Berahovich, R., Xu, S., Quintanilla, M., Ma, M. C., Sienkiewicz, J., Huang, Y., & Wu, L. (2021). Novel CD37, Humanized CD37 and Bi-Specific Humanized CD37-CD19 CAR-T Cells Specifically Target Lymphoma. Cancers, 13(5), 981. |
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CAR Construction : 2B8D12F2D4 scFv-41BB-CD28ζ
Fig.2 Fluorescence-activated cell sorting assay. FACS with mouse F(ab)2 antibody (mFAB) detected CAR-positive cells. Golubovskaya, V., Zhou, H., Li, F., Valentine, M., Sun, J., Berahovich, R., Xu, S., Quintanilla, M., Ma, M. C., Sienkiewicz, J., Huang, Y., & Wu, L. (2021). Novel CD37, Humanized CD37 and Bi-Specific Humanized CD37-CD19 CAR-T Cells Specifically Target Lymphoma. Cancers, 13(5), 981. |
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CAR Construction : 2B8D12F2D4 scFv-41BB-CD28ζ
Fig.3 Cytotoxicity assay. Real-time cytotoxicity assay (RTCA) showed specific killing activity of CD37-CAR-T cells against CHO-CD37 cells but not CHO cells. Golubovskaya, V., Zhou, H., Li, F., Valentine, M., Sun, J., Berahovich, R., Xu, S., Quintanilla, M., Ma, M. C., Sienkiewicz, J., Huang, Y., & Wu, L. (2021). Novel CD37, Humanized CD37 and Bi-Specific Humanized CD37-CD19 CAR-T Cells Specifically Target Lymphoma. Cancers, 13(5), 981. |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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