All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
Sleeping Beauty (SB) transposon, a type of nonviral integrative vectors, provides an alternative to modify primary T cells. Creative biolabs has developed SB transposon CAR vector pSBCAR1 CD3D (G19-4) h(28ζ), which is constructed for the engineering of T cells to target human CD3D. The T cells are genetically modified through transduction with a nonviral vector expressing scFv of anti-CD3D antibody linked to CD28 and CD3ζ signaling domains. And the vector product was designed for the treatment of Endometrial cancer.
CAR Construction : Fig.1 Affinity between CD3ed±Ig and anti-CD3 mAbdetermined by surface plasmon resonance. The affinity of interaction between CD3ed±Ig and anti-CD3 wasdetermined by SPR in which graded concentrations of CD3ed±Ig in liquid phase were allowed to bind anti-CD3 mAbimmobilized on chips. Law, C. L., Hayden‐Ledbetter, M., Buckwalter, S., McNeill, L., Nguyen, H., Habecker, P., ... & Ledbetter, J. A. (2002). Expression and characterization of recombinant soluble human CD3 molecules: presentation of antigenic epitopes defined on the native TCR–CD3 complex. International immunology, 14(4), 389-400. |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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