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Anti-DLL3 TCR-ABR-α (XW-310) CAR Vector (XS-1122-YF1230)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-DLL3 TCR-fused Antigen Binding Receptor (TCR-ABR) CAR is constructed for the engineering of T cells to target Human DLL3. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv (XW-310) of anti-DLL3 antibody linked to TCRα subunit. The vector product was designed for the discovery and development of cellular therapy against Lung malignancy. The TCR-ABR can effectively reprogram an intact TCR complex to recognize tumor surface antigens. TCR-ABR-T cells are shown to engage the signaling capacity of the entire TCR complex in an HLA-independent manner.

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Details

  • Target
  • DLL3
  • Targeting Cell Type
  • T Cell
  • Targeting Diseases
  • Lung malignancy
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • scFv-TCRα
  • Discription of Signaling Cassetes
  • The scFv used to generate CAR-T cells or single domain antibodies can be fused to the extracellular N-termini of TCRα, TCRβ, CD3γ, CD3δ, or CD3ε subunits, resulting in the activation of target-specific TCR-ABR-T cells. TCR-ABR-T cells have been shown to use the entire TCR complex's signaling capacity in an HLA-independent manner.

Target

  • Clone
  • XW-310
  • Host
  • Mouse
  • Target Species
  • Human
  • Gene Name
  • delta like canonical Notch ligand 3
  • Synonyms
  • DLL3; delta-like 3 (Drosophila); SCDO1; delta-like protein 3; delta3; drosophila Delta homolog 3
  • Introduction
  • This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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