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Anti-fbpB T cell receptor ((TCR052)-1), pCDTCR1 (TCR-YC0397)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-fbpB T cell receptor (TCR) is constructed for the engineering of T cell to target Diacylglycerol acyltransferase/mycolyltransferase Ag85B (PSMGRDIKVQFQSGG) restricted by HLA-DRB1*03:01. The T cells are genetically modified through transduction with a lentiviral vector expressing fbpB-specific T cell receptor.

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Details

  • Target
  • fbpB
  • Target Species
  • Mycobacterium tuberculosis
  • Epitope
  • PSMGRDIKVQFQSGG
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-DRB1*03:01
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • TCR052
  • Host Species
  • Human

Target

  • Introduction
  • The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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