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The vector of anti-FLT3 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human FLT3. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-FLT3 antibody linked to 41BB and CD3ζ signaling domains. And the vector product was designed for the treatment of Acute lymphoblastic leukemia (ALL).
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CAR Construction :
Fig.1 Flow cytometry analysis of the FLT3 expression in blood immune cell subsets using anti-FLT3 CLONE 4G8. Percentage of FLT3-expressing cells in the indicated blood immune cell subsets. Bone marrow HSPCs (CD34+CD38+) are also depicted for comparison. N=6 monkeys. FLT3 was detected by BV10 antibody. Yeung, Y. A., Krishnamoorthy, V., Dettling, D., Sommer, C., Poulsen, K., Ni, I., ... & Djuretic, I. (2020). An optimized full-length FLT3/CD3 bispecific antibody demonstrates potent anti-leukemia activity and reversible hematological toxicity. Molecular Therapy, 28(3), 889-900. |
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