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Anti-α-GalCer T cell receptor ((NKT15)-2), pCDTCR1 (TCR-YC1419)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-α-GalCer T cell receptor (TCR) is constructed for the engineering of T cell to target 4′-deoxy α-GalCer restricted by human CD1d. The T cells are genetically modified through transduction with a lentiviral vector expressing α-GalCer-specific T cell receptor.

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Details

  • Target
  • α-GalCer
  • Epitope
  • 4′-deoxy α-GalCer
  • Format
  • Non-Modified TCR
  • Allele
  • human CD1d
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • NKT15
  • Host Species
  • Human

Target

  • Introduction
  • alpha-Galactosylceramide (α-GalCer, KRN7000) is a synthetic glycolipid derived from structure-activity relationship studies of galactosylceramides isolated from the marine sponge Agelas mauritianus. α-GalCer is a strong immunostimulant and shows potent anti-tumour activity in many in vivo models. α-GalCer is a potent activator of iNKT cells, and a model CD1d antigen. The invariant T cell receptor of the iNKT cell is able to bind the CD1d:glycolipid complex leading to iNKT cell in both mice and humans.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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