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Anti-Human DLL3 (XW-311)-BBZ CAR mRNA LNP (XS-0822-YF5831)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

mRNA LNP is mRNA encapsulation in lipid nanoparticles. Creative Biolabs produces CAR mRNA LNPs with our proprietary production platform, ensuring the quality and expression efficiency. This product is anti-DLL3 scFv (XW-311)-BBZ chimeric antigen receptor (CAR) mRNA LNP which can be used for CAR expression in various immune cells. The CAR mRNA LNP can be conjugated with specific antibody for specific cell targeting.

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CAR Information

  • Target Species
  • Human
  • Clone
  • XW-311
  • Host
  • Humanized
  • CAR Construction
  • scFv-41BB-CD3ζ
  • CAR Generation
  • Second
  • CAR Signaling Description
  • 41BB
    CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigen-nonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.

CAR mRNA Properties

  • Cap
  • Cap 1
  • PolyA
  • Segmented PolyA
  • Product Type
  • CAR mRNA LNP
  • Lipid Mixture
  • Ethanolic lipid mixture of ionizable cationic lipid, phosphatidylcholine, cholesterol and polyethylene glycol-lipid, or based on specific requirements.
  • Storage
  • Aliquot and store at -80°C. Avoid freeze/thaw cycles.

mRNA Quality Control

  • OD260/280
  • PASS
  • Agarose Gel Mobility
  • PASS
  • IVT Vector Sequencing
  • PASS
  • IVT Vector Enzyme Digestion
  • PASS
  • mRNA Transfection Efficiency
  • PASS
  • CAR Expression after mRNA Transfection
  • PASS

Target Information

  • Target
  • DLL3
  • Gene Name
  • DLL3
  • Full Name
  • delta like canonical Notch ligand 3
  • Introduction
  • This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene.
  • Related Diseases
  • Lung malignancy
  • Alternative Names
  • DLL3; delta-like 3 (Drosophila); SCDO1; delta-like protein 3; delta3; drosophila Delta homolog 3

Customer Reviews and Q&As

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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