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Anti-PB1-F2 T cell receptor (2557), pCDTCR1 (TCR-YC0855)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-PB1-F2 T cell receptor (TCR) is constructed for the engineering of T cell to target PB1-F2 protein (LSLRNPILV) restricted by H2-Dᵇ. The T cells are genetically modified through transduction with a lentiviral vector expressing PB1-F2-specific T cell receptor.

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Details

  • Target
  • PB1-F2
  • Target Species
  • IAV
  • Epitope
  • LSLRNPILV
  • Format
  • Non-Modified TCR
  • Allele
  • H2-Dᵇ
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • 2557
  • Host Species
  • Mouse

Target

  • Introduction
  • Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS. Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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