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Anti-pM45 T cell receptor (1903), pCDTCR1 (TCR-YC1017)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The TCR clone recognizes HGIRNASFI in the context of Db class I molecule.

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Details

  • Target
  • pM45
  • Target Species
  • MuHV1
  • Epitope
  • HGIRNASFI
  • Format
  • Non-Modified TCR
  • Allele
  • H2-Db
  • Targeting Diseases
  • Herpesvirus infection
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • 1903
  • Host Species
  • Mouse

Target

  • Introduction
  • Murine CMV (MCMV) is a natural herpesvirus infection of mice and thus provides a good model to study the effects of immune evasion on the host immune response. This paper investigates the effect of an immune evasion gene that profoundly inhibits presentation of a viral epitope on the immunodominance of that epitope. MCMV encodes three genes, m4, m6, and m152, which interfere with Ag presentation to CD8 T cells. The m4/gp34 protein binds to MHC class I molecules in the endoplasmic reticulum (ER) and on the cell surface. The m6/gp48 protein redirects class I to the lysosome for degradation. Finally, m152 retains class I in the ER cis-Golgi intermediate compartment.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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