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The overtly diabetogenic character of CD4 T cells bearing the BDC-2.5, BDC-10.1, or BDC-6.9 TCR is shown, for example, in engineered NOD mice expressing retrovirus-encoded TCRs (TCR retrogenics [Rgs]). Unlike TCRs reacting with insulin, IA2β, or GAD65 epitopes, which induced limited or no disease, both BDC-2.5 and BDC-10.1 TCRs induced insulitis and 100% diabetes incidence, with a lower ID₅₀ value in the case of the BDC-10.1 TCR. In comparison, the diabetogenic potential of the BDC-6.9 TCR was less marked in the Rg setting, yet ∼60% of BDC-6.9 TCR–Rg mice became diabetic. In addition, diabetes is accelerated in some BDC-6.9 TCR–transgenic (Tg) mice.
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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