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Anti-Sulfatide T cell receptor (BC8B), pCDTCR1 (TCR-YC1129)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-Sulfatide T cell receptor (TCR) is constructed for the engineering of T cell to target Sulfatide restricted by human CD1b. The T cells are genetically modified through transduction with a lentiviral vector expressing Sulfatide-specific T cell receptor.

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Details

  • Target
  • Sulfatide
  • Epitope
  • Sulfatide
  • Format
  • Non-Modified TCR
  • Allele
  • human CD1b
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • BC8B
  • Host Species
  • Human

Target

  • Introduction
  • Sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside, is a class of sulfolipids, specifically a class of sulfoglycolipids, which are glycolipids that contain a sulfate group. Sulfatide is synthesized primarily starting in the endoplasmic reticulum and ending in the Golgi apparatus where ceramide is converted to galactocerebroside and later sulfated to make sulfatide. Of all of the galactolipids that are found in the myelin sheath, one fifth of them are sulfatide. Sulfatide is primarily found on the extracellular leaflet of the myelin plasma membrane produced by the oligodendrocytes in the central nervous system and in the Schwann cells in the peripheral nervous system. However, sulfatide is also present on the extracellular leaflet of the plasma membrane of many cells in eukaryotic organisms.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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