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Anti-UL49 T cell receptor (16), pCDTCR1 (TCR-YC1287)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

One epitope, amino acids 49-57 of virion protein 22 (VP22), encoded by gene UL49, is immunodominant in terms of cell number and population prevalence when referenced to the current integrated data set. Amongst persons with the restricting HLA B*0702 allele, about 50% have CD8 (+) lymphocytes in peripheral blood at a level high enough to detect with direct staining with tetramers of HLA B*0702 and the peptide (sequence RPRGEVRFL). EC50 value of TCR clone 16 is 28.5 nM for cytotoxicity.

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Details

  • Target
  • UL49
  • Target Species
  • HHV2
  • Epitope
  • RPRGEVRFL
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-B*07:02
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • 16
  • Host Species
  • Human

Target

  • Introduction
  • Tegument protein that plays different roles during the time course of infection. Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection. Modulates the RNase activity of the virion host shutoff protein UL41 probably to ensure necessary levels of key cellular mRNAs and proteins. Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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