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The vector of anti-CD20 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human CD20. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CD20 antibody linked to CD28 and CD3ζ signaling domains. And the vector product was designed for the treatment of NHL.
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CAR Construction :
Fig.1 Analysis of antibody binding to CD20 + CHO by whole cell ELISA. Antibody reactivity to CD20 + CHO fixed on a PLL plate was tested. Nishida, M., Usuda, S., Okabe, M., Miyakoda, H., Komatsu, M., Hanaoka, H., ... & Niwa, O. (2007). Characterization of novel murine anti-CD20 monoclonal antibodies and their comparison to 2B8 and c2B8 (rituximab). International journal of oncology, 31(1), 29-40. |
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CAR Construction :
Fig.2 The anti-CD20 binding activity of CD20-binding polypeptide compositions and immunocytokines. Human Daudi lymphoma cells were incubated with varying concentrations of polypeptide compositions and ICs and relative binding to the cells was assessed by flow cytometry. Carr, F. J., Williams, S., & Gillies, S. D. (2012). U.S. Patent No. 8,147,832. Washington, DC: U.S. Patent and Trademark Office. |
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