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The vector of anti-FLT3 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human FLT3. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-FLT3 antibody linked to 41BB and CD3ζ signaling domains. And the vector product was designed for the treatment of Acute myeloid leukemia (AML).
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CAR Construction :
Fig.1 Binding of clone EB10 to cell surface-expressed EB10. FLT3-positive EOL-1 and EM3 (both with wild-type receptor), BaF3/FLT3-ITD and MV4-11 (both with FLT3-ITD mutations), or FLT3-negative JM1 cells were incubated with clone EB10. Williams, B., Atkins, A., Zhang, H., Lu, D., Jimenez, X., Li, H., ... & Zhu, Z. (2005). Cell-based selection of internalizing fully human antagonistic antibodies directed against FLT3 for suppression of leukemia cell growth. Leukemia, 19(8), 1432-1438. |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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