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The vector of anti-GD2 chimeric antigen receptor(CAR) is constructed for the engineering of NK cells to target Human GD2. The NK cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-GD2 antibody linked to FcεRIγ signaling domains. And the vector product was designed for the treatment of neuroblastoma and melanoma.
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CAR Construction : 14.18 scfv-CD28-41BB-CD3ζ
Fig.1 GD2-CAR T cell killing assay. Target cell killing analysis of the GD2 CAR T cells, 14.18. The OS cells transduced with a lentiviral wasabi green fluorescence reporter gene were used as target cells, Chulanetra, M., Morchang, A., Sayour, E., Eldjerou, L., Milner, R., Lagmay, J., ... & Chang, L. J. (2020). GD2 chimeric antigen receptor modified T cells in synergy with sub-toxic level of doxorubicin targeting osteosarcomas. American journal of cancer research, 10(2), 674. |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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