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pCDTRC1 CD30 ε-TRuC (XS-0123-ZP689)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The T cell receptor fusion construct (TRuC) comprising an antibody-based binding domain fused to T cell receptor (TCR) subunit can effectively reprogram an intact TCR complex to recognize tumor surface antigens. Unlike CAR, TRuC become a functional component of the TCR complex. TRuC-T cells kill tumor cells as potently as second-generation CAR-T cells, but at significant lower cytokine release and despite the absence of an extra co-stimulatory domain.

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Details

  • Target
  • CD30
  • Targeting Cell Type
  • T cell
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • scFv-CD3ε

Target

  • Clone
  • SH313B5
  • Host
  • Mouse
  • Target Species
  • Human
  • Gene Name
  • TNF receptor superfamily member 8
  • Synonyms
  • CD30;TNFRSF8; TNF receptor superfamily member 8; CD30; Ki-1; D1S166E;

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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