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TRAC-ROR1 (X3XT148) h(ICOSBBζ) replaced CAR Vector (XS-0323-LX4430)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The product TRAC-ROR1 (X3XT148) h(ICOS-4-1BB-CD3ζ) replaced CAR, pcDNA Vector is a TRAC-replaced CAR constructed for the engineering of T cells/other T cell lines to target human ROR1. This plasmid is a donor template for integration directing a ROR1 (X3XT148) h(ICOSBBζ) CAR to the T-cell receptor α constant (TRAC) locus by using CRISPR/cas9 technology, this precise approach resulted in CAR T cells with more stamina. And the vector product was designed for the research of Cancer.

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Details

  • Target
  • ROR1
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Cancer
  • Generation
  • Third
  • Vector Name
  • pcDNA Vector
  • Vector Length
  • ~6kb
  • Vector Type
  • Nonviral
  • Receptor Construction
  • Homology arm-EF1a-scFv-ICOS-41BB-CD3ζ-Homology arm
  • Discription of Signaling Cassetes
  • ICOS
    CD278 or ICOS (Inducible T-cell COStimulator) is a CD28-superfamily costimulatory molecule that is expressed on activated T cells. It is thought to be important for Th2 cells in particular. The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
    41BB
    CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigen-nonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ, ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric ICOS and 4-1BB can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.

Target

  • Clone
  • X3XT148
  • Host
  • Rabbit
  • Target Species
  • Human
  • Gene Name
  • Receptor tyrosine kinase like orphan receptor 1
  • Synonyms
  • ROR1; NTRKR1; dJ537F10.1

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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