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TS-IL15 SA Anti-PD-1 (XW-739) BBζ CAR (XS-0822-YF10325)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-Human PD-1 chimeric antigen receptor (CAR) is constructed for the engineering of T cells. The receptor construction is 7H-YB-IL15 SA-EF1a-scFv-41BB-CD3ζ. 7H-YB means seven repeats of the HSE motif 5'-nGAAnnTTCnnGAAn-3' upstream of the human synthetic core promoter (YB). 7H-YB is a technology for photothermal control of T cell therapies.

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Details

  • Target
  • PD-1
  • Targeting Diseases
  • Glioblastoma; Triple-negative Breast Cancer
  • Generation
  • 2nd-generation CAR
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • 7H-YB-IL15 SA-EF1a-scFv-41BB-CD3ζ

Target

  • Clone
  • XW-739
  • Host
  • Human
  • Target Species
  • Human
  • Gene Name
  • programmed cell death 1
  • Synonyms
  • PD-1; PDCD1
  • Introduction
  • Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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