Anti-OR9Q2 (FLFTFFASI) TCR (BC7), Jurkat Cell Line (TCRJ-YF217)

Online Inquiry Datasheet

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The anti-OR9Q2 (FLFTFFASI) TCR Jurkat cell line is a stable cell line made from the anti-OR9Q2 TCR lentivirus. The recombinant Jurkat T cell was designed to predict the MOA of OR9Q2-TCR, measure the OR9Q2-TCR specificity and screen target cells expressing OR9Q2. And the product can be used to treat Cancer.

Specifications

Cell Background
The Jurkat cell line was established from the peripheral blood of human T lymphocyte cells. Jurkat cells are used to study acute T cell leukemia, T cell signaling, and the expression of various chemokine receptors. Jurkat cells can produce interleukin 2, and are used in research involving the susceptibility of cancers to drugs and radiation.

Cell Type
T lymphocyte

Formulation
Containing ≥ 1 X 10*6 / vial frozen cells

Cell Purity
>95%

Cell Viability
>90%

Mycoplasma Testing
The cell line has been screened using the luciferase based mycoplasma detection kit to confirm the absence of mycoplasma species.

Applications
• Screen for activators or inhibitors of OR9Q2 signaling in a cellular context
• Characterize the biological activity of OR9Q2 and its interactions with ligands
• Predict the MOA of the TCR design
• Screen and validate OR9Q2-expressing target cells

Storage
Frozen cells should be stored in a liquid nitrogen tank (-150°C~-190°C). Once reconstituted, the cells may be used for up to five days if properly stored at 2°C - 8°C in the buffer provided.

Handling Notes
Frozen cells should be thawed immediately upon receipt and grown according to handling procedure to ensure cell viability and proper assay performance.
Note: Do not freeze the cells upon receipt as it may result in irreversible damage to the cell line.
Disclaimer: We cannot guarantee cell viability if the cells are not thawed immediately upon receipt and grown according to handling procedure.

Warnings
Avoid multiple freeze/thaw cycles

Research Use Only
Our recombinant Jurkat cell are for research use only, not for diagnostic or therapeutic use.

Quality Control
Cultures are screened for the presence of bacteries, yeast, fungi and mycoplasma (DNA amplification). Growth media are also certified based on U.S. Public Health Service Guidelines.

Tumorgenicity
Positive (In vitro/vivo transformation assay)

Oncogenicity
Positive (In vitro soft agarose assay and life-time studies )

Sterility Testing
Creative Biolabs provides sterility testing in accordance with USP and EP regulations. All of our sterility testing is performed in an isolator or clean room environments. The cell line has been screened using the membrane filtration testing methods to confirm the absence of aerobic, anaerobic and fungi microorganisms.

Identity Testing
Identity testing is required for newly established cell lines. Isoenzyme analysis is used to confirm the identity of the species of a cell line. Alternative methods for identity testing include DNA fingerprinting, STR analysis and karyology.

Virological Safety Testing
A broad range of viruses is susceptible to affecting human cell lines. We can provide in vivo/vitro virus saftey assays by utilizing various animal systems. These viruses include: adventitious viruses, bovine viruses, human and simian viruses, porcine viruses, retrovirus and rodent viruses.

Genetic Stability Testing
We perform cell genetic stability studies under ICH guidelines. We
can provide guidance on the appropriate testing program upon your requirements.

TCR Design

Target
OR9Q2

Introduction
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

HLA
HLA-A*02:01

Common Name
OR9Q2

Target Species
Human

TCR Clone
BC7

TCR-Host Animal
Human

Vector Name
pCDTCR1

Vector length
~ 8 kb

Vector Type
Lentiviral vector

Targeting Diseases
Cancer

Epitope
FLFTFFASI

Format
Non-modified

GeneID
219957

UniProt ID
Q8NGE9

Customer Reviews and Q&As

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-OR9Q2 (FLFTFFASI) TCR (BC7), Jurkat Cell Line (TCRJ-YF217)

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Specifications

TCR Design

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