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Anti-SLC30A8 T cell receptor (UH4), pCDTCR1 (TCR-YC1101)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-SLC30A8 T cell receptor (TCR) is constructed for the engineering of T cell to target Solute carrier family 30 member 8 (VVTGVLVYL) restricted by HLA-A*02:01. The T cells are genetically modified through transduction with a lentiviral vector expressing SLC30A8-specific T cell receptor.

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Details

  • Target
  • SLC30A8
  • Target Species
  • Human
  • Epitope
  • VVTGVLVYL
  • Format
  • Non-Modified TCR
  • Allele
  • HLA-A*02:01
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~ 8 kb
  • Vector Type
  • Lentiviral vector
  • TCR Clone
  • UH4
  • Host Species
  • Human

Target

  • Introduction
  • The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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