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CLDN18A2 is the stomach isoform of CLDN18. CLDN18 is a protein that in humans is encoded by CLDN18 gene. It belongs to the group of claudins, a large family of proteins which form tight junction strands in epithelial cells. Since claudin-18 (Cldn18) is overexpressed in precursor lesion PanIN and pancreatic duct carcinoma, it serves as a diagnostic marker and a target of immunotherapy.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-LC199 | Anti-CLD18A2 (163) h(CD3ζ) CAR, pCDCAR1 | Human | 163 | Mouse | scFv-CD3ζ | Lentiviral | T cell | ||
| CAR-LC200 | Anti-CLD18A2 (163) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 | Human | 163 | Mouse | scFv-CD28-41BB-CD3ζ | Lentiviral | T cell | ||
| CAR-LC201 | Anti-CLD18A2 (175) h(CD3ζ) CAR, pCDCAR1 | Human | 175 | Mouse | scFv-CD3ζ | Lentiviral | T cell | ||
| CAR-LC202 | Anti-CLD18A2 (175) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 | Human | 175 | Mouse | scFv-CD28-41BB-CD3ζ | Lentiviral | T cell | ||
| XS-0722-ZP4431 | Anti-CLDN18A2 ('8E5) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | ‘8E5 | Humanized | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| XS-0722-ZP4642 | Anti-CLDN18A2 ('8E5) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | ‘8E5 | Humanized | scFv-4-1BB-CD3ζ | Lentiviral vector | T cell |
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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