In Vitro Toxicity

To optimize the lead and generate a candidate, Creative Biolabs offers comprehensive and impeccable services of in vitro toxicity testing. As a critical part in drug safety profiles, toxicity assessment is a major reason for program termination and market withdrawal. To save time and avoid the cost, we help our clients to evaluate the in vitro potential toxicity of lead at an early stage. With the continuous development of various in vitro screening and modeling, we have established a wide range of integrated in vitro toxicity testing services as a rapid, high-efficient and cost-effective choice for our clients to evaluate drug safety profiles.

Capabilities

In Vitro Toxicity Studies

Creative Biolabs offers a wide range of in vitro toxicity studies to fulfill your comprehensive requirements.

Cytotoxicity

We offer a variety of cytotoxicity assays using a panel of cell proliferation and viability tests.

• Enzyme Leakage Assays
• Membrane Impermeable Dyes
• Amine-reactive Dyes
• Dye Combination Assays
• Cell Viability Assays
• Apoptosis Assays
• Cell Proliferation/Cell Cycle Assays

Gene Toxicity

We employ a broad range of genotoxicity liability detection assays in compliance with GLP and non-GLP to detect cellular DNA damage.

• Mutation test in bacteria and mammalian cell lines
• Chromosome aberrations
• Micronucleus test

Cardiotoxicity

Integrated with iPS/ES-derived cardiomyocytes and in silico techniques, our experts perform a variety of high-throughput tests to identify the compounds, which potentially interfere with cardiac physiology or functions.

• Ion channel assay
• hERG screening
• Cardiac action potential assay
• In silico 3D-based structural model

Hepatotoxicity

Incorporated with high content analysis, we offer hepatotoxicity studies to minimize the liability of drug-induced liver toxicity.

• Cell-based hepatotoxicity assay
• 3D-based microtissue assay

Ophthalmic Toxicity

We offer the following tests to estimate the ocular toxicity which is essential for IND submission.

• Ocular irritation test
• Short time exposure (STE) for severe eye damage

Creative Biolabs is dedicated to delivering comprehensive in vitro toxicity studies to help our clients optimize and select the compounds for your program. If you have any requests (not limited to the studies in the table), please contact us for more detailed information or send us an inquiry directly.