Preclinical Testing

As an experienced CRO in the field of cancer immunotherapy discovery and development, Creative Biolabs has developed into the best trusted partner who is fully competent and dedicated to providing a suite of standalone or integrated services throughout the life cycle of drug discovery and development, including discovery, biologics testing, development, preclinical testing, manufacturing, as well as regulatory services.

Background

Drug discovery and development pathway is a long journey, and complications and inefficiencies at the late stage can create costly delays. Therefore, safety and efficacy profiles assessments of drug candidates prior to clinical trials are critical stages to avoid unnecessary loss. Preclinical testing in animal models can help to foreseen potential risks of drug candidates before exposure to humans, and hence reduce the cost for pharmaceutical industries and help to make the appropriate choice. Now immunotherapy has emerged as a major approach to treat malignancies including small chemical molecules and biologics drugs, we are dedicated to serving preclinical testing for immunotherapy potential drugs.

Fig.1 Schematic diagram of our end-to-end drug discovery and development services.

Introduction of Preclinical Testing Services

Creative Biolabs is dedicated to providing flexible solutions and accelerated timelines for our clients who care about making a difference for immuno-oncology. Our experienced scientists and skillful technicians execute individual studies via state-of-the-art technologies in a global worldwide network of facilities. Furthermore, custom preclinical testing studies which are designed to fit client’s goals are also available in Creative Biolabs. Our regulatory experts ensure that all preclinical testing services are in compliance with worldwide standards for quality and regulations to smooth the path to market. Here are our provided services for your quick check but not limited to these.

Efficacy Models

Creative Biolabs is committed to conducting non-GLP and GLP efficacy in vivo studies to meet the needs of our clients. We offer efficacy models including cell line derived xenograft models, humanized models, immuno-deficient mice, syngeneic models and chemical-induced cancer model to support different oncology areas that incorporate biomarkers and outcome measures to enable greater success in the clinic. The appropriate model will be designed to meet their scientific objectives, and custom studies will be designed and custom protocols and statements of work (SOWs) will be developed to meet quality assurance guidelines.

Antibody and Protein Pharmacology

Our pharmacology program helps clients to accelerate the development of their cancer immunotherapy candidates via investigating the potential actions of compounds or biologics on physiological functions under exposure in the therapeutic range and above. We offer a comprehensive, harmonized, global pharmacology program in compliance with the ICH guidelines.

Antibody and Protein Toxicology

Empowered by our board-certified toxicologists, veterinary surgeons, veterinary pathologists, regulatory specialists and support technicians, Creative Biolabs has designed and performed toxicology programs over decades. These programs cover a wide range of animal models and employ various routes of administration, and evaluate acute through chronic toxicity and carcinogenicity.

Purpose of Our Immuno-Oncology Preclinical Animal Testing

Highlight Features of Our Services

  • ✔ Around 100 studies completed every year;
  • ✔ With a globally advanced platform empowered with various technologies;
  • ✔ An integrated and multi-disciplinary approach.

Creative Biolabs is committed to end-to-end immuno-oncology preclinical animal testing be compliance with ICH guidelines to meet regulatory requirements. Our experienced team helps clients to avoid roadblocks, anticipate challenges, and expedite preclinical drug development with a wide array of services and expert guidance through this important stage. If you want to have a further communication or any other requests, please feel free to contact us.

For lab research only, cannot be used for any clinical use.

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