Target | ATP7B |
Immunogen | Human ATPase, Cu++ transporting, beta polypeptide |
Species Reactivity | Human |
Application | WB, ELISA, IHC, FuncS, Cell Penetration |
Clone | WJ206 |
Host Animal | Llama |
Isotype | sdAb |
Clonality | Monoclonal |
Class | Primary |
Concentration | 1 mg/mL |
Conjugation | snGFP |
Storage Condition | Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles. |
Target Background | This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). |
Target Synonym | ATP7B; ATPase, Cu++ transporting, beta polypeptide; WD; PWD; WC1; WND; copper-transporting ATPase 2; copper pump 2; Wilson disease-associated protein; ATPase, Cu(2+)- transporting, beta polypeptide |
Gene ID | 540 |
UniProt ID | A0A024RDX3 |
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