Discovery of Anti-drug sdAb for Drug Candidate Evaluation
In the field of the novel single domain antibody (sdAb) development, Creative Biolabs is a well-recognized expert who can offer the best one-stop solution for our customers all over the world. With our extensive experience and advanced platforms, our scientists are confident in developing the high specific anti-drug sdAb to meet the requirement of your drug discovery project.
Characterization and Isolation of Drug Candidate
In the past few decades, therapeutic antibodies as drug candidates have been rapidly developed from clinical trials to the markets; they show several promising characteristics, such as excellent solubility, high specificity, and low risk. The handy and robust tool is required to monitor therapeutic antibodies in patient serum, in this case, anti-idiotypic antibodies (also known as anti-drug antibodies) which can specifically bind to the therapeutic antibodies are employed as a promising tool in the preclinical and clinical development process. It can be used as detection reagents of antibody drugs’ pharmacokinetic/pharmacodynamics (PK/PD) analysis, as well, the detection and characterization of anti-drug antibody can be a standard to evaluate the immunogenicity issues caused by antibody drugs. Besides, the high-specific anti-drug antibody can also serve as a capturing agent for antibody drugs in complex samples, as a tool for immunoaffinity enrichment even further as the reagent for purification of antibody drugs.
Fig.1 Anti-drug sdAb for isolation of antibody drugs. (Könning, et al., 2017)
Anti-drug sdAb represents an ideal class of high-quality reagents suitable for therapeutic antibodies’ research. The generation of anti-drug sdAb can be a straightforward process by using our advanced phage display platform. Anti-drug sdAb which has high specificity and affinity can be used as the desired monitor for antibody drugs. Meanwhile, anti-drug sdAb has tremendous thermal and physical stability and can tolerate some strict conditions, such as possible extreme acid-base conditions or low and high-temperature conditions. Moreover, anti-drug sdAb can refold completely after denaturation to enable reusability which makes it a reliable tool for capture and purification antibody drugs. These unique properties make anti-drug sdAb perfectly suitable for the characterization and isolation of the drug candidates. Creative Biolabs can provide one-stop solution for anti-idiotypic sdAb development for the generation of anti-drug sdAb with our extensive experience in sdAb discovery and development.
Main Applications of Anti-drug sdAb
- Characterization and monitoring of antibody drugs in vivo
- Antibody drugs pharmacokinetic/pharmacodynamics (PK/PD) studies
- Antibody drugs immunogenicity (immune response, IR) studies
- Preclinical and clinical studies of antibody drugs
- Isolation, purification, and enrichment of antibody drugs
- Various immunoassay tools in clinical development
Along with over a decade of extensive experience and advanced platform, Creative Biolabs is always devoted to offering the best novel single domain antibody development solutions for our customers all over the world. If you are interested in our sdAb development service, please feel free to contact us for more details.
Reference
- Könning, D.; et al. Semi-synthetic vNAR libraries screened against therapeutic antibodies primarily deliver anti-idiotypic binders. Scientific reports. 2017, 7(1): 1-13.
Case Study
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Applications
