Target | C. difficile Toxins A/B |
Immunogen | Toxins A/B |
Species Reactivity | C. difficile |
Application | WB, ICC, ChIP, ELISA, Cell Penetration |
Clone | WJ238 |
Host Animal | Llama |
Isotype | sdAb |
Clonality | Monoclonal |
Class | Primary |
Concentration | 1 mg/mL |
Conjugation | sn-mNeptune |
Storage Condition | Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles. |
Target Background | Pathogenic C. difficile strains produce several known toxins. The most well-characterized are enterotoxin (toxin A) and cytotoxin (toxin B), both of which are responsible for the diarrhea and inflammation seen in infected patients, although their relative contributions have been debated. Toxins A and B are glucosyltransferases that target and inactivate the Rho family of GTPases. Toxin B (cytotoxin) induces actin depolymerization by a mechanism correlated with a decrease in the ADP-ribosylation of the low molecular mass GTP-binding Rho proteins. |
Target Synonym | tcdA; toxA; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium; Clostridium difficile Toxin A; C. difficile Toxin B; Clostridium difficile Toxin B; Cytotoxin B; tcdB; toxB; Toxin B |
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