Target | Casp4 |
Immunogen | Mouse caspase 4, apoptosis-related cysteine peptidase |
Species Reactivity | Mouse |
Application | WB, IP, ICC, FC, Cell Penetration |
Clone | WJ254 |
Host Animal | Llama |
Isotype | sdAb |
Clonality | Monoclonal |
Class | Primary |
Concentration | 1 mg/mL |
Conjugation | snGFP |
Storage Condition | Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles. |
Target Background | This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4, apoptosis-related cysteine peptidase", this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9. |
Target Synonym | Casp4; caspase 4, apoptosis-related cysteine peptidase; Caspl; ich-3; CASP-4; Casp11; CASP-11 |
Gene ID | 12363 |
UniProt ID | P70343 |
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