Super™ Llama Anti-Crotoxin Single Domain Antibody-snGFP (WJ302)(Cat#: MDWJ3070)
This product is a Llama single domain antibody recognizes Crotoxin conjugated to snGFP. This product has the ability for cell penetration.
Datasheets| Target | Crotoxin |
| Immunogen | Crotoxin |
| Species Reactivity | N/A |
| Application | WB, IP, ICC, FC, Cell Penetration |
| Clone | WJ302 |
| Host Animal | Llama |
| Isotype | sdAb |
| Clonality | Monoclonal |
| Class | Primary |
| Concentration | 1 mg/mL |
| Conjugation | snGFP |
| Storage Condition | Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles. |
| Target Background | Crotoxin is a cytotoxic PLA23 compound isolated from a South American snake, Crotalus durissus terrificus, venom. It is a noncovalent complex formed by two nonidentical subunits, one acidic (subunit A ∼9.5 kDa) and one basic (subunit B ∼14.5 kDa). Subunit B is a PLA2 formed by a single chain of 122 amino acid residues cross-linked by seven disulfide bonds. Subunit A is formed by three polypeptide chains cross-linked by seven disulfide bonds, is devoid of catalytic activity, has no affinity for membranes, and is nontoxic (LD50 i.v. mice> 20 mg/kg; Ref. 6 ). The two subunits form spontaneously a tight 1:1 complex. Crotoxin displays cytotoxic activity against a variety of murine and human tumor cell lines in vitro, which require both the PLA2 activity of subunit B and the ability of the complex to dissociate into their subunits. Crotoxin-induced cytotoxic effects appear to be highly selective toward cell lines expressing a high density of epidermal growth factor receptors, thus suggesting that epidermal growth factor receptors, or a receptor function, play a role in targeting. |
| Target Synonym | crotoxin; venom; Crotalus durissus terrificus; cytotoxic PLA23 |
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KINDLY NOTE
- Some properties of custom products can be tailored flexibly. Please feel free to send your specific demands through an inquiry.
- All listed customized sdAb products are for lab research use only, not intended for pharmaceutical, diagnostic, therapeutic or any in vivo human use. For commercial purpose, please review our one-stop solutions for de novo sdAb discovery.
- No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
- NCBI/UniProt data is used to refer general target information. It may not necessarily be applicable to one specific product.
- Creative Biolabs has made every effort to ensure the accuracy of the datasheet and reserves the right to make changes to the datasheet at any time without prior notice. Creative Biolabs will not be liable for any omissions or errors contained herein, please use the COA of your custom products as standard.
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For Research Use Only. Not for diagnostic or therapeutic applications.
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