Target | Diap1 |
Immunogen | Mouse diaphanous homolog 1 (Drosophila) |
Species Reactivity | Mouse |
Application | WB, ICC, ChIP, ELISA, Cell Penetration |
Clone | WJ317 |
Host Animal | Llama |
Isotype | sdAb |
Clonality | Monoclonal |
Class | Primary |
Concentration | 1 mg/mL |
Conjugation | spGFP |
Storage Condition | Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles. |
Target Background | This gene encodes a member of the formin family of proteins that play important roles in cytoskeletal rearragnement by nucleation of actin filaments. Mice lacking the encoded protein develop age-dependent myeloproliferative defects resembling human myeloproliferative syndrome and myelodysplastic syndromes. Trafficking of T lymphocytes to secondary lymphoid organs and, egression of thymocytes from the thymus are impaired in these animals. Lack of the encoded protein in T lymphocytes and thymocytes also reduces chemotaxis. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Target Synonym | Diap1; diaphanous homolog 1 (Drosophila); Dia1; Drf1; Diaph1; p140mDia; D18Wsu154e |
Gene ID | 13367 |
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