Super™ Llama Anti-E. coli Heat-labile enterotoxin Single Domain Antibody-snGFP (WJ331)(Cat#: MDWJ3300)
This product is a Llama single domain antibody recognizes E. coli Heat-labile enterotoxin conjugated to snGFP. This product has the ability for cell penetration.
Datasheets| Target | E. coli Heat-labile enterotoxin |
| Immunogen | Heat-labile enterotoxin |
| Species Reactivity | E. coli |
| Application | WB, ICC, ChIP, ELISA, Cell Penetration |
| Clone | WJ331 |
| Host Animal | Llama |
| Isotype | sdAb |
| Clonality | Monoclonal |
| Class | Primary |
| Concentration | 1 mg/mL |
| Conjugation | snGFP |
| Storage Condition | Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles. |
| Target Background | The heat labile enterotoxin is inactivated at high temperatures. It acts similarly to the cholera toxin by raising cAMP levels through ADP-ribosylation of the alpha-subunit of a Gs protein leading to the constitutive activation of adenylate cyclase. Elevated cAMP levels stimulate The activation of the CFTR channel thus stimulating secretion of Chloride ions and water from the enterocyte into the gut lumen. This ionic imbalance causes watery diarrhea. In addition to its effects on chloride secretion, which involve the same steps as the effects of cholera toxin, heat-labile enterotoxin binds additional substrates: lipopolysaccharide on the surface of E. coli cells and A-type blood antigens. |
| Target Synonym | heat labile enterotoxin; heat-labile enterotoxin |
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KINDLY NOTE
- Some properties of custom products can be tailored flexibly. Please feel free to send your specific demands through an inquiry.
- All listed customized sdAb products are for lab research use only, not intended for pharmaceutical, diagnostic, therapeutic or any in vivo human use. For commercial purpose, please review our one-stop solutions for de novo sdAb discovery.
- No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
- NCBI/UniProt data is used to refer general target information. It may not necessarily be applicable to one specific product.
- Creative Biolabs has made every effort to ensure the accuracy of the datasheet and reserves the right to make changes to the datasheet at any time without prior notice. Creative Biolabs will not be liable for any omissions or errors contained herein, please use the COA of your custom products as standard.
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For Research Use Only. Not for diagnostic or therapeutic applications.
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