Target | Fcgr3 |
Immunogen | Mouse Fc receptor, IgG, low affinity III |
Species Reactivity | Mouse |
Application | IHC, FC, FuncS, Cell Penetration |
Clone | WJ364 |
Host Animal | Llama |
Isotype | sdAb |
Clonality | Monoclonal |
Class | Primary |
Concentration | 1 mg/mL |
Conjugation | snGFP |
Storage Condition | Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles. |
Target Background | An Fc receptor is a protein found on the surface of certain cells – including, among others, B lymphocytes, follicular dendritic cells, natural killer cells, macrophages, neutrophils, eosinophils, basophils and mast cells – that contribute to the protective functions of the immune system. Its name is derived from its binding specificity for a part of an antibody known as the Fc (Fragment, crystallizable) region. Fc receptors bind to antibodies that are attached to infected cells or invading pathogens. Their activity stimulates phagocytic or cytotoxic cells to destroy microbes, or infected cells by antibody-mediated phagocytosis or antibody-dependent cell-mediated cytotoxicity. Some viruses such as flaviviruses use Fc receptors to help them infect cells, by a mechanism known as antibody-dependent enhancement of infection. |
Target Synonym | FCGR3; Fc receptor, IgG, low affinity III; CD16; low affinity immunoglobulin gamma Fc region receptor III; Fc gamma receptor III; Fcg receptor III; FcgammaRIII; fc-gamma RIII; fcRIII; igG Fc receptor III |
Gene ID | 14131 |
UniProt ID | E9PUV2 |
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