Target | gp120 |
Immunogen | The details of the immunogen for this antibody are not available. |
Species Reactivity | Human immunodeficiency virus 1 |
Application | Cell Penetration |
Clone | A12 |
Host Animal | Llama |
Isotype | sdAb |
Clonality | Monoclonal |
Class | Primary |
Concentration | 1 mg/mL |
Conjugation | snGFP |
Storage Condition | Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles. |
Target Background | HIV1 is equipped with the envelope gp160 glycoprotein for interaction with Langerhans cells (LCs) and dendritic cells (DCs), the members of the innate immune system, which confront the virus at the portal of virus entry in the human body. These cells are equipped with receptors by which they bind and endocytose the virus. The gp120 glycoprotein is used for binding to CD4 receptor and CCR5 co-receptor of T helper 2 (Th2) cells, and is able to induce FcepsilonRI(+) hematopoietic cells to produce IL4, which inactivates the host adaptive immune response. |
Target Synonym | ENV;gp160;envelope glycoprotein;Envelope surface glycoprotein gp160, precursor;hypothetical protein;Envelope surface glycoprotein gp120;Envelope transmembrane domain;CD3E;CD3e molecule, epsilon (CD3-TCR complex);T3E;TCRE;IMD18;T-cell surface glycoprotein CD3 epsilon chain;CD3-epsilon;T-cell surface antigen T3/Leu-4 epsilon chain;CD3e antigen, epsilon polypeptide (TiT3 complex);T-cell antigen receptor complex, epsilon subunit of T3;ADIS;Bi-specific T-cell engagers;BiTE |
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