Target | HIV-1 env |
Immunogen | human immunodeficiency virus type 1 gp160; envelope glycoprotein |
Species Reactivity | HIV-1 |
Application | ELISA, IHC, FC, FuncS, Cell Penetration |
Clone | WJ430 |
Host Animal | Llama |
Isotype | sdAb |
Clonality | Monoclonal |
Class | Primary |
Concentration | 1 mg/mL |
Conjugation | snGFP |
Storage Condition | Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles. |
Target Background | Many viruses (e.g. influenza and many animal viruses) have viral envelopes covering their protective protein capsids.The envelopes typically are derived from portions of the host cell membranes (phospholipids and proteins), but include some viral glycoproteins. Functionally, viral envelopes are essential for entry into host cells. They may help viruses avoid the host immune system. Glycoproteins on the surface of the envelope serve to identify and bind to receptor siteson the host's membrane. The viral envelope then fuses with the host's membrane, allowing the capside and viral genome to enter and infect the host. The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and acquired immunodeficiency syndrome (AIDS). AIDS is a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. Infection with HIV occurs by the transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk. Within these bodily fluids, HIV is present as both free virus particles and virus within infected immune cells. |
Target Synonym | ENV; gp160; envelope glycoprotein; Envelope surface glycoprotein gp160, precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain |
Gene ID | 155971 |
UniProt ID | P04578 |
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