Target | HIV-1 Nef |
Immunogen | HIV-1 p27 |
Species Reactivity | HIV-1 |
Application | WB, FuncS, Cell Penetration |
Clone | sdAb19 |
Host Animal | Llama |
Isotype | sdAb |
Clonality | Monoclonal |
Class | Primary |
Concentration | 1 mg/mL |
Conjugation | snGFP |
Storage Condition | Store at 4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles. |
Target Background | The HIV Nef protein is a multifunctional virulence factor that perturbs intracellular membranes and signalling and is secreted into exosomes. While Nef-containing exosomes have a distinct proteomic profile, no comprehensive analysis of their miRNA cargo has been carried out. Since Nef functions as a viral suppressor of RNA interference and disturbs the distribution of RNA-induced silencing complex proteins between cells and exosomes, we hypothesized that it might also affect the export of miRNAs into exosomes. |
Target Synonym | HIV Nef; Human Immunodeficiency Viruse Nef; Human Immunodeficiency Viruse; HIV Nef protein; HIV Nef-protein |
Gene ID | 156110 |
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